Rafael Davalos

L. Preston Wade Professor


Area(s) of Interest: Biomechanics, Translational Cancer Research
Phone: (540) 231-1979
Email: davalos@vt.edu
Bioelectromechanical Systems Laboratory

329 Kelly Hall
325 Stanger Street (MC 0298)
Blacksburg, VA 24061

EDUCATION:

  • Ph.D., University of California - Berkeley; Bioengineering
  • M.S., University of California - Berkeley; Mechanical Engineering
  • B.S., Cornell University - Mechanical and Aerospace Engineering

RESEARCH INTERESTS:

  • Biomedical microdevices
  • Irreversible electroporation
  • Dielectrophoretic cell manipulation
  • Image-guided surgery
  • Single cell analysis
  • Cancer detection and treatment
  • BioMEMS

AWARDS:

  • Invited Speaker: Gordon Conference on Bioelectrochemistry July 1-6, Lucca, Italy, 12
  • Invited Speaker: XXX URSI General Assembly and Scientific Symposium, August 13-20, Istanbul, Turkey, 11
  • College of Engineering Faculty Fellow: College of Engineering, Virginia Tech, 11-14
  • NSF CAREER Award Recipient: National Science Foundation, 11
  • Invited Speaker: Electric Fields Effects in Tumors Workshop. IEEE EMBS, Argentina, 10
  • Invited Speaker: 7th International Bioelectrics Symposium. Norfolk, VA, 10
  • Invited Speaker: Engineering Platforms for Exploring Cellular and Molecular Processes. U Louisville, 10
  • Invited Speaker: Thermal Biology and Therapy Workshop. U Minnesota, 10
  • Invited Speaker: Society for CNS Interstitial Delivery of Therapeutics. Cleveland, OH, 09
  • Invited Speaker: 36th FACSS Conference. Louisville, KY, 09
  • Plenary Speaker: 45th Annual Meeting of the Society for Cryobiology. Charlotte NC, 08
  • Outstanding New Assistant Professor Award: College of Engineering, Virginia Tech, 09
  • Early Career Award: Wallace H. Coulter Foundation, 08 - 12
  • National Award Recipient: HENAAC - Most Promising Engineer or Scientist, 06

RECENT PUBLICATIONS:

  • RE Neal II, JH Rossmeisl Jr, PA Garcia, O Lantz, N Henao-Guerrero, RV Davalos. Successful treatment of a large soft-tissue sarcoma with irreversible electroporation. Journal of Clinical Oncology, vol 29(13), pp 372-377, 2011. (IF 17.793)
  • PA Garcia, JH Rossmeisl, RE Neal II, TL Ellis, RV Davalos. A parametric study delineating irreversible electroporation from thermal damage based on a minimally invasive intracranial procedure, Biomedical Engineering Online, vol 10:34, 2011 - Highly Accessed - 2011 (IF 1.639)
  • CB Arena, MB Sano, MN Rylander, RV Davalos. Theoretical considerations of tissue electroporation with high frequency bipolar pulses. IEEE Transactions on Biomedical Engineering, in print. (IF 2.154)
  • MB Sano, RE Neal II, PA Garcia, D Gerber, J Robertson, RV Davalos. Towards the creation of organ constructs using irreversible electroporation and active mechanical perfusion. Biomedical Engineering Online, vol 9(83), 2011 - Highly accessed (IF 1.639)
  • PA Garcia, T Pancotto, JH Rossmeisl Jr, N Henao-Guerrero, NR Gustafson, GB Daniel, JL Robertson, TL Ellis, RV Davalos. Non-thermal irreversible electroporation (N-TIRE) and adjuvant fractionated radiotherapeutic multimodal therapy for intracranial malignant glioma in a canine patient. Technology in Cancer Research and Treatment, vol 10(1), pp 73-83, 2011. (IF 2.032)
  • TL Ellis, PA Garcia, JH Rossmeisl Jr, NH Guerrero, J Robertson, RV Davalos. Non-thermal irreversible electroporation (N-TIRE) for intracranial surgical applications. Journal of Neurosurgery, vol 114(3), pp 681-688, 2011. (IF 2.594)
  • PA Garcia, JH Rossmeisl, RE Neal II, TL Ellis, J Olson, N Henao-Guerrero, J Robertson, RV Davalos. Intracranial non-thermal irreversible electroporation: In vivo analysis, Journal of Membrane Biology, vol 236(1), pp 127-136, 2010. (IF 2.189)
  • MB Sano, A Rojas, P Gatenholm, RV Davalos. Dielectrophoretic Microweaving: Biofabrication of aligned bacterial cellulose nanofibrils. Annals of Biomedical Engineering, vol 38(8), pp 2475-2484, 2010. (IF 2.409)
  • H Shafiee, JL Caldwell, RV Davalos. A microfluidic system for biological particle enrichment utilizing contactless dielectrophoresis (cDEP) (invited paper). Journal of the Association for Laboratory Automation (JALA), vol 15(3), pp 224-232, 2010. (IF New Journal)
  • RE Neal II, R Singh, H Hatcher, S Torti, RV Davalos. Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode. Breast Cancer Research and Treatment, vol 123, pp 295-301, 2010. (IF 4.696)
  • H Shafiee, MB Sano, E Henslee, JL Caldwell, RV Davalos. Selective isolation of live-dead cells using contactless dielectrophoresis (cDEP). Lab on a Chip (cover), vol 10, pp 438-445, 2010. (IF 6.342)
  • RE Neal II, RV Davalos. The feasibility of irreversible electroporation for the treatment of breast cancer and other heterogeneous systems. Annals of Biomedical Engineering, vol 37(12), pp 2615-2625, 2009. (IF 2.409)
  • H Shafiee, JL Caldwell, MB Sano, RV Davalos. Contactless dielectrophoresis for particle manipulation on-chip. Biomedical Microdevices, vol 11(5), pp 997-1006, 2009. (IF 3.323)
  • JF Edd, RV Davalos. Mathematical modeling of irreversible electroporation for treatment planning. Technology in Cancer Research and Treatment, v6:275-286, 2007.
  • RV Davalos, GJ McGraw, TI Wallow, AM Morales, KL Krafcik, GJ Fiechtner, Y Fintschenko, EB Cummings, BA Simmons. The application of insulator-based dielectrophoresis polymer microfluidic devices as particle separators and the impact of dynamic surface coatings on performance. Analytical and Bioanalytical Chemistry, v389:1426-1425, 2007.
  • R.V. Davalos, Y. Huang and B. Rubinsky, "Electroporation: bio-electrochemical mass transfer at the nano scale," Microscale Thermophysical Engineering, vol. 4, pp. 147-159, 2000.
  • R.V. Davalos, D.M. Otten and B. Rubinsky, "A feasibility study for electrical impedance tomography as a means to monitor tissue electroporation for molecular medicine," IEEE Transactions on Biomedical Engineering, vol. 49(4), pp. 400-403, 2002.
  • R.V. Davalos, B. Rubinsky and L.M. Mir, "Theoretical analysis of the thermal effects during in vivo tissue electroporation," Bioelectrochemistry, vol. 61(1-2), pp. 99-107, 2003.
  • R.V. Davalos and B. Rubinsky, "Electrical impedance tomography of cell viability in tissue with application to cryosurgery," Journal of Biomechanical Engineering, vol. 126(2), pp. 305-309, 2004.
  • R.V. Davalos, B.H. Lapizco-Encinas, G.J. Fiechtner, A.K. Singh, B.A. Simmons, Y. Fintschenko and E.B. Cummings, "A performance comparison of post- and ridge-based dielectrophoretic particle sorters," Royal Society of Chemical Special Publications, 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Malmo, Sweden, Sep 26-30, no. 296, pp. 650-652, 2004.
  • R.V. Davalos, D.M. Otten, L.M. Mir and B. Rubinsky, "Electrical impedance tomography for imaging tissue electroporation," IEEE Transactions on Biomedical Engineering, vol. 51(5) pp. 761-767, 2004.
  • R.V. Davalos, L.M. Mir and B. Rubinsky, "Tissue ablation with irreversible electroporation," Annals of Biomedical Engineering, vol.33(2), pp. 223-231, 2005.
  • R.G. Guerra, R.V. Davalos, P.A. Garcia, B. Rubinsky and M.S. Berger, "A heat transfer model to characterize the focal cooling necessary to suppress spontaneous Epileptiform activity," SPIE Proceedings: PW05B Biomedical Optics - Thermal Treatment of Tissue: Energy Delivery and Assessment VI, San Jose, CA, Jan 25-27, vol. 5698(23), pp. 240-246, 2005.
  • B.H. Lapizco-Encinas, R.V. Davalos, B.A. Simmons, E.B. Cummings and Y. Fintschenko, "An insulator-based (electrodeless) dielectrophoretic concentrator for microbes in water," Journal of Microbiological Methods, vol. 62, pp. 317-326, 2005.
  • G.J. McGraw, R.V. Davalos, B.M. Mittal, S.M. Ferko, M.C. Hunter, J.D. Brazzle, Y. Fintschenko, E.B. Cummings and B.A. Simmons, "Scalability of insulator-based dielectrophoresis (iDEP) and its utilization as a high-throughput particle concentrator," Royal Society of Chemical Special Publications, 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences , Boston, MA, Oct 9-13, pp. 705-708, 2005.
  • M. Khine, A. Lau, C.I. Zanetti, J. Seo, E.S. Lee, R.V. Davalos and L.P. Lee, "A low-voltage single cell electroporation array for intracellular compound delivery," Royal Society of Chemical Special Publications, 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Boston, MA, Oct 9-13, pp. 856-858, 2005.
  • B.A. Simmons, G.J. McGraw, R.V. Davalos , G.J. Fiechtner, Y. Fintschenko and E.B. Cummings, "Development of polymeric devices as dielectrophoretic separators and concentrators," MRS Bulletin , vol. 31, pp. 120-124, 2006.
  • E.S. Lee, D. Robinson, J.L. Rognlien, C.K. Harnett, B.A. Simmons, C.R.B. Ellis and R.V. Davalos, " Robust giant lipid vesicles and micro-electroporation technology for controllable manipulation of picoliter volumes on-chip," Bioelectrochemistry, vol. 69, pp. 117-125, 2006.
  • P. Ponce, B.A. Simmons, M. Khine, and R. V. Davalos, " A bioparticle detector using integrated insulator-based dielectrophoresis and bioimpedance measurements," Royal Society of Chemical Special Publications, 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences , Tokyo, Japan, Nov 5-9, pp. 987-989, 2006.
  • E.S. Lee, S.S. Bachelor, Z.Q. Iqbal, L.P. Lee and R.V. Davalos, "Viability after on-chip single-cell micro-electroporation for the study of macrophage signaling pathways," Royal Society of Chemical Special Publications, 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences , Tokyo, Japan, Nov 5-9, pp. 1345-1347, 20

On Friday, 2/17, at 4 PM there will be a BME Minor Information Session held in Hancock 100.

 

Summer research experience for undergraduates

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