Pamela VandeVord

N. Waldo Harrison Professor and Biomedical Engineering Program Chair, Interim Department Head


Area(s) of Interest: Biomechanics, Nanomedicine and Nanobioengineering, Neuroengineering
Phone: (540) 231-1994
Email: pvord@vt.edu
Traumatic Nerve Technologies

317 Kelly Hall, 325 Stanger Blacksburg, VA 24061

EDUCATION:

  • Ph.D., Wayne State University, Detroit, MI, 2002
  • M.S., Wayne State University, Detroit, MI, 1996
  • B.S., Michigan State University, East Lansing, MI, 1992

RESEARCH INTERESTS:

  • Cell and Tissue Injury Biomechanics
  • Neurotrauma
  • Nerve Regeneration
  • Biomaterials

TEACHING INTERESTS:

  • Molecular and Cell Biology
  • Physiology
  • Biocompatibility

RECENT PUBLICATIONS:

  • Sajja VS, Perrine SA, Ghoddoussi F, Hall CS, Galloway MP, *VandeVord* PJ. Blast neurotrauma impairs working memory and disrupts prefrontal myo-inositol levels in rats. Mol Cell Neurosci. 2014 Feb 15;59C:119-126
  • Ereifej ES, Cheng MM, Mao G, VandeVord PJ. Examining the inflammatory response to nanopatterned polydimethylsiloxane using organotypic brain slice methods. J Neurosci Methods. Jul 15;217(1-2):17-25 (2013)
  • Hockey KS, Hubbard WB, Sajja VS, Sholar CA, Thorpe C, VandeVord PJ, Rzigalinski BA. A new model for mild blast injury utilizing Drosophila melanogaster. Biomed Sci Instrum. 49:134-40 (2013)
  • Ereifej ES, Khan S, Newaz G, Zhang J, Auner GW, VandeVord PJ. Comparative assessment of iridium oxide and platinum alloy wires using an in vitro glial scar assay. Biomed Microdevices (2013)
  • Cho HJ, Sajja VS, VandeVord PJ, Lee YW. Blast induces oxidative stress, inflammation, neuronal loss and subsequent short-term memory impairment in rats. Neuroscience; 3;253C:9-20. (2013)
  • Hampton CE, Thorpe CN, Sholar CA, VandeVord PJ. A novel bridge wire model of blast traumatic brain injury Biomed Sci Instrum;49:312-9 (2013)
  • Leonardi AC, Keene, N. Bir CA, VandeVord PJ. Head Orientation Affects the Intracranial Pressure Response Resulting from Shock Wave Loading in the Rat, Journal of Biomechanics; Oct 11;45(15):2595-602 (2012)
  • Sajja VS, Galloway M, Ghoddoussi F, Kepsel A, VandeVord PJ. Effects of Blast-Induced Neurotrauma on the Nucleus Accumbens. J Neurosci Res, Apr;91(4):593-601 (2013)
  • Bou-Akl TH, Banglemaier R, Miller, R, VandeVord PJ. Effect of crosslinking on the mechanical properties of mineralized and non mineralized collagen fibers. J Biomed Mater Res A. Sep;101(9):2507-14. (2013)
  • Mao J, Pace E, Pierozynski P, Kou Z, Shen Y, VandeVord PJ, Haacke EM, Zhang X, Zhang J. Blast-Induced Tinnitus and Hearing Loss in Rats: Behavioral and Imaging Assays. J Neurotrauma; Jan;20(2):430-44 (2012)
  • VandeVord PJ, Bolander R, Sajja VS, Bir CA. Mild Neurotrauma Indicates a Range Specific Pressure Response to Low Level Shock Wave Exposure. Annals of Biomedical Engineering; Jan;40(1):227-36 (2012)
  • Bir C, VandeVord PJ, Shen Y, Haacke EM. Effects of Variable Blast Pressures on Blood Flow and Oxygen Saturation in Rat Brain as Evidenced using MRI. Magnetic Resonance Imaging; May;30(4):527-34 (2012)
  • Sajja VS, Galloway M, Ghoddoussi F, Thiruthalinathan D, Kepsel A, Hay K, Bir CA, *VandeVord PJ.* Blast-induced neurotrauma leads to neurochemical changes and neuronal degeneration in the rat hippocampus. NMR Biomedicine; Dec;25(12):1331-9 (2012)
  • Leonardi AC, Keene, N. Bir CA, *VandeVord PJ.* Head Orientation Affects the Intracranial Pressure Response Resulting from Shock Wave Loading in the Rat, Journal of Biomechanics; Oct 11;45(15):2595-602 (2012)
  • Sajja VS, Tenn C, McLaws LJ, VandeVord, PJ. A Temporal Evaluation of Serum Cytokines In Rats After Blast Exposure. Biomed Sci Instrumentation; 48:374-9 (2012)
  • Hampton, CE and VandeVord, PJ. Vibrational Frequency Response to Impact Loading of Skull Models. Biomedical Sciences Instrumentation, 48:157-64. (2012)
  • Kane M, Angoa-Perez M, Francescutti D, Sykes C, Briggs C, Leung LY, VandeVord PJ, Kuhn D. Altered Gene Expression in Cultured Microglia in Response to Simulated Blast Overpressure: Possible Role of Pulse Duration, Neurosci Letters: Jul 26;522(1):47-51 (2012)
  • Ereifej ES, Matthew HW, Newaz G, Mukhopadhyay A, Auner G, Salakhutdinov I, *VandeVord PJ*. Nanopatterning Effects on Astrocyte Reactivity, Journal of Biomedical Materials Research A: Nov 27 (2012)
  • Bhatti G, Jayanthi L, *VandeVord PJ*, Gebremichael Y. Computational investigation of the key factors affecting the second stage activation mechanisms of domain II m-calpain. Journal of Molecular Modeling; Oct 10 (2012)
  • Bolander R, Mathie BA, Bir CA, Ritzel D, VandeVord PJ. The Contribution of Skull Flexure as a Possible Mechanism for Neurotrauma in the Rat when Exposed to a Shock Wave. Annals of Biomedical Engineering; Jul (2011)
  • Ereifej ES, Khan S, Newaz G, Zhang J, Auner G, VandeVord PJ. Characterization of Astrocyte Reactivity and Gene Expression on Biomaterials for Neural Electrodes. Journal of Biomedical Materials Research A; 99(1): 141-50 (2011)
  • Leonardi AC, Bir CA, Ritzel D, VandeVord PJ. Intracranial pressure increases during exposure to a shock wave. J Neurotrauma. Jan;28(1):85-94 (2011)
  • VandeVord PJ, Broadrick KM, Krishnamurthy B, Singla A. A Comparative Study Evaluating the In Vivo Incorporation of Biological Sling Materials. Urology, 75 (5):1228-1233 (2010)
  • de Guzman R, Loeb J, VandeVord PJ. Electrospinning of matrigel to deposit a basal lamina-like nanofiber surface. Journal of Biomaterials Science. 21: 1081-1101 (2010)
  • Adler JE, Nico L, VandeVord PJ, Skoff AM. Modulation of neuropathic pain by a glial-derived factor. Pain Med. 10(7):1229-1236 (2009)
  • Patel M, Mao L, Wu B, VandeVord PJ. GDNF Blended Chitosan Nerve Guides: An In Vivo Study. Journal of Biomedical Materials Research A. 90(1):154-65 (2009)
  • Hao HN, Peduzzi-Nelson JD, VandeVord PJ, Barami K, DeSilva SP, Pelinkovic D, Morawa LG. Lipopolysaccharide-induced inflammatory cytokine production by Schwann's cells dependent upon TLR4 expression. J Neuroimmunol, 25;212(1-2):26-34 (2009)
  • Yu H, VandeVord PJ, Mao L, Matthew HW, Wooley PH, Yang SY. Improved Tissue-Engineered Bone Regeneration by Endothelial Cell Mediated Vascularization. Tissue Engineering Part A, 14(5):743-743 (2008)
  • de Guzman R, Ereifej ES , Broadrick KM, Rogers RA, VandeVord PJ. Alginate-matrigel microencapsulated Schwann cells for inducible secretion of glial cell line derived neurotrophic factor. Journal of Microencapsulation, 17:1-12 (2008)
  • Leung LY, VandeVord PJ, Leonardi A, Bir C, Yang KH, King AI. Blast related neurotrauma: A review of cellular injury. Molecular & Cellular Biomechanics, 5(3):155-68 (2008)
  • VandeVord PJ, Leung LY, Hardy W, Yang KH, King AI. Up-regulation of proliferation and survival genes in astrocytes after exposing to short duration overpressure. Neuroscience Letters, 4;434(3):247-52 (2008)